Pharmacological effect of Nolvadex

admin   December 26, 2015   Comments Off on Pharmacological effect of Nolvadex

Composition

In one tablet of tamoxifen citrate, 10 mg or 20 mg.

Product form

Tablets coated with 10 and 20 mg.

Pharmachologic effect

Antiestrogens (prevents the formation of female sex hormones), antitumor.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Nolvadex – a non-steroidal estrogen antagonist. Specifically binds to estrogen receptors in peripheral and tumor tissues. Thus, eliminating the effect of
estrogen produced in the body and stimulate the growth of cancer cells.

Slows the progression of cancer. After receiving a single dose of a few weeks will continue to block the ability of estrogen. Triggers ovulation in women,
in men with oligospermia it increases the level of LH and FSH. More details.

Pharmacokinetics

If ingestion is rapidly absorbed, and after 5-7 hours in the blood creates a maximum concentration. 99% associated with blood proteins (albumin). Excretion
occurs dwuhfazno: Initial T 1/2 from 8 to 14 hours, the final T 1/2 – 7 days. Excreted in the feces, only a small portion of the urine.

Indications

Nolvadex is used for:

  •  estrogen-dependent mammary tumors in postmenopausal women;
  •  endometrial cancer.

Contraindications

Nolvadex tablets are contraindicated in:

  • hypersensitivity;
  • pregnancy;
  • breastfeeding;
  • cataracts;
  •  expressed thrombophlebitis;
  •  leukopenia, thrombocytopenia.

 

Side effects

Nolvadex may cause the following adverse reactions:

  • dizziness;
  •  gastrointestinal disorders and nausea;
  •  uterine bleeding, endometrial hyperplasia, uterine fibroids, itching of the vulva;
  •  fluid retention;
  • hypercalcemia;
  •  thrombocytopenia, leukopenia;
  • alopecia;
  •  bone pain;
  •  changes in the retina;
  • thromboembolism.

Instructions for use (method and dosage)

Nolvadex tablets taken by mouth without chewing, drinking water. You can receive the entire dose at once in the morning or two doses – in the morning and
evening. When breast cancer is prescribed 20-40 mg, endometrial cancer – 30-40 mg. Maximum SD- 40 mg. Treatment for a long time, often in combination with
cytostatic and radiation therapy.

During treatment, control blood clotting, leukocytes, platelets, calcium levels in the blood, liver function. Ophthalmologist examines quarterly and
gynecological examination. Nolvadex drug is ineffective in the presence of metastasis (especially in liver). Read more.

Overdose

Manifested increased side effects. Symptomatic treatment. There is no antidote.

Interaction

Nolvadex (Tamoxifen) enhances the effect of anticoagulants. Simultaneous administration of the drug to estrogensoderjath contraceptives decreases the
effect of both drugs.

Application with tegafur can lead to hepatitis and cirrhosis of the liver. Allopurinol also enhances its hepatotoxic effects.

Joint reception with cytostatics significantly increases the risk of blood clots.

Admission thiazide diuretics number increases the risk of hypercalcemia.

H2-blockers of histamine receptors and antacids can cause premature dissolution of the enteric tablets, so the time between taking these medications should
be 2 hours.

Terms of sale

Tablets Nolvadex prescription.

Storage conditions

At a temperature of up to 30C.

Shelf life

5 years.

Analogs

Vero-Tamoxifen, Tamifen, Tamoxifen, Tamoxifen hexane Zitazonium, Tamaksin, Tamofen, Tamoksifer citrate, Tamopleks, Valodeks, Tsitofen, Nolte, Zemid.

Reviews

Although tamoxifen is used to treat and prevent recurrence of breast cancer since 1998, and it can now be regarded as the “gold standard” in the treatment
of this disease. Nolvadex, or substitutes, and today is used in oncology, as evidenced by reviews of patients who for a long time prescribe this drug.

“Delete the right breast, after a course of radiation therapy was prescribed Tamoxifen for 5 years”

It has been proven that the efficacy increases at long reception and immediately began to appoint five years of continuous use. This reduces the mortality
of patients after discontinuation and longer life for decades. Treatment allows estrogen antagonists prevent tumor metastasis. After this period, the
oncologist evaluates the condition and concludes: extend the treatment, adding cytotoxic drugs or aromatase inhibitors.

According to some reports the drug is effective only in older women. After prolonged use of the drug observed adverse reactions reported by patients: pain
in the hip joints, weight gain, hair loss, varicose veins and thrombophlebitis, itching.

The drug can be administered as a prophylactic measure, and for the prevention of breast cancer in women who are predisposed to this disease. Received
concrete evidence that the drug reduces the risk of one-third of breast cancer. However, it found an unexpected side effect – there is the risk of uterine
sarcomas. On this issue, there are discussions going on, and clinical trials. Tamoxifen for the prevention, the physician should discuss with the patient
the benefit of the drug and the existing risk. Find more info.

Price, where to buy

At the moment, buy Nolvadex in pharmacies in Moscow and other Russian cities impossible due to the expiry of the registration of the drug.

The pharmacy offers Vero Tamoxifen 20mg number 30 at the price of 107-126 rubles., Hexane Tamoxifen 10mg №30 cost 99-114 rubles, and Tamoxifen Ebewe.